Dados do Trabalho

Name: Congresso SONO 2022
Start: 2022-11-30
End: 2022-12-03
Location: Centro de Convenções de Goiânia

Título

Do women with dysmenorrhea present altered sleep and inflammatory mediators’ levels?

Introdução

Painful menstruation is the main symptom of dysmenorrhea, a dysfunction that affects more than 50% of women during reproductive phase. It is a recurrent inflammatory pathology that can strongly impact women’s life by causing academic and work absenteeism, social problems, lower performance, and sleep complaints.

Objetivo

The objective of this study was to analyze the level of inflammatory mediators and the sleep of women with dysmenorrhea (Dysm) during menstruation (Menst) and compare them to healthy women and among non-menstruated (Non-Menst) and oral contraceptive (OC) use women.

Métodos

We distributed 328 women into 6 groups: Dysm+Menst (n=35); Dysm+NonMenst (n=83); Dysm+OC (n=45); Menst (n=26); NonMenst (n=88) and OC (n=51). All these groups have undergone a one-night polysomnography (PSG) and had IL-6, Tumor Necrosis Factor (TNF) and C-reactive protein (CP) measured. Menstruation and painful menstruation episodes were asked and reported on the night of the PSG by gynecological questionnaire to enable group distribution. For statistical analysis, we used Generalized Linear Model, and Sequential Bonferroni post hoc test which corrects for multiple comparisons.

Resultados

The groups of Dysm+NonMenst and Dysm+Menst showed lower sleep efficiency (82.8%±1.54;79.7%±2.4, respectively) when compared to group using OC (88.8%±0.99). The CP was found significantly increased in Dysm+OC women (0.45mg/dL±0.05) when compared to NonMenst (0.27mg/dL±0.02) and Dysm+NonMenst (0.24mg/dL±0.02) women. The TNF level was statistically higher in NonMenst women (9.9pg/mL±0.69) compared to Menst women (7.73pg/mL±0.67). Sleep latency, total sleep time, awakenings/hour, N1, N2, N3, REM sleep and IL-6 had not presented any statistical differences among the groups investigated.

Conclusões

Our results indicated that dysmenorrhea did not affect the sleep efficiency of women using OC; however, this condition was related to increased cardiovascular risk in these women.