Dados do Trabalho

Título

Association of adiponectin, leptin and daytime sleepiness in women with severe obesity

Introdução

Metabolic alterations such as Insulin Resistance (IR), hyperleptinemia, and hypoadiponectinemia, are prevalent conditions in the obesity epidemic and are often associated with sleep disorders, worsening quality of life. Adipokines such as leptin and adiponectin have a pro-inflammatory and anti-inflammatory character, respectively. Individuals with obesity often present hypoadiponectinemia and hyperleptinemia state, which are associated with a worsening in sleep quality, duration, apnea, and sleep disorders when evaluated by polysomnography. However, more viable and practical tools such as questionnaires should be studied for the daily clinical practice.

Objetivo

Assess whether daytime sleepiness is associated with ratios of adiponectin/leptin and leptin/adiponectin in women with severe obesity.

Métodos

Forty-five women that were on the waiting list for bariatric surgery at a public hospital in Goiânia were included. Weight, height, and circumferences of the neck (NC), waist (WC), and hips (WC) were measured. Daytime sleepiness was assessed by Epworth Sleepiness Scale (ESS), blood samples were collected for analysis of glycemic parameters, lipid profile and adipokines. Leptin and adiponectin concentrations were determined by ELISA enzyme immunoassay method. Statistical analyzes were performed in SPSS. Data normality was verified by the Shapiro Wilk Test and Generalized Linear Models (GLZM) were used to compare the groups. Spearman/Pearson’s correlation was performed to verify the correlation between sleep disorders and other variables. Volunteers were grouped according to the ESS classification into excessive (EDS) and Normal daytime sleepiness.

Resultados

The total sample had an average age of 40.1 ± 8.59 years; 48.19 ± 7.05 kg/m² of BMI; and increased circumferences. The prevalence of worst sleep quality was 42.2%. Individuals with EDS had a higher leptin/adiponectin ratio (p=0.009), lower adiponectin/leptin ratio (p=0.007). Positive correlation between ESS and glycated hemoglobin (p= 0.00; r= 0.647) was found.

Conclusões

Women with severe obesity and excessive daytime sleepiness has higher pro-inflammatory and decreased anti-inflammatory ratios. Also, is possible to observe an association of ESS and metabolic parameters.Thus, ESS proved to be a tool to be considered in clinical practice, correlating with inflammatory and metabolic parameters in women with severe obesity. Funding: CNPq/FUNAPE

Palavras -chave

Leptin, Adiponectin, Daytime Sleepiness