Dados do Trabalho

Título

Relationship of sleep and metabolic syndrome parameters in women with severe obesity

Introdução

Obesity seems to be linked by a bidirectional mechanism with sleep disorders and both are risk factors for the development of metabolic syndrome (MS). The MS is a complex set of factors that significantly increases the risk of cardiovascular diseases.

Objetivo

To evaluate excessive daytime sleepiness (EDS) in women with severe obesity and its relationship with MS and its parameters

Métodos

Women with a body mass index (BMI) greater than or equal to 40 kg/m² were recruited. At the first outpatient consultation, weight, height, waist (WC) and hip (HC) circumferences were measured and blood samples were collected to analyze the levels of fasting glucose, insulin, glycated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), high (HDL-c) and low density (LDL-c) lipids. It was calculated the values of HOMA-IR and HOMA-β and systolic (SBP) and diastolic blood pressure (DBP) data were obtained from medical records. The Epworth Sleepiness questionnaire was applied and women were classified with EDS when Epworth score ≥ to 11 . Moreover, volunteers were identified with MS according to the criteria of the International Diabetes Federation (2005) and sleep duration was asked. The Shapiro-Wilk test was used to analyze the normality of the variables, the univariate GLM test was used to compare the mean between the groups and the Pearson and Spearman correlation tests were applied.

Resultados

Forty-three women participated of the study with a mean age of 40.12 ± 8.41 years and a BMI of 48.63 ± 6.87, with 76.74% (n=33) having MS and 44.2% (n =19) showed EDS. In the group with MS, the Epworth questionnaire score correlated with age (p=0.031 rho=0.376), DBP (p=0.021 rho=0.400) and TG/HDL-c ratio (p=0.049 rho=0.345) and sleep duration with glucose (p=0.034 rho= -0.370) and HbA1c (p=0.008 rho= -0.453). Similarly, in the total sample, sleep duration correlated with glucose (p=0.052 rho=-0.299), HbA1c (p=0.019 rho=-0.357) and additionally with DBP (p=0.057 rho=-0.293).

Conclusões

Data suggest that sleep duration in severe obesity is correlated with one of the main pathophysiological markers of MS. Among women with MS, the age seems to be an important factor to be considered to evaluate sleep quality
CNPq Edital n°434159/2018-2; FUNAPE: nº01/2022

Palavras -chave

Excessive daytime sleepiness; Metabolic syndrome; obesity; sleep duration

Área

Área Clínica